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Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging

2005; National Academy of Sciences; Volume: 102; Issue: 51 Linguagem: Inglês

10.1073/pnas.0509419102

1091-6490

Galina E. Pavlovskaya, Zackary I. Cleveland, Karl F. Stupic, Randall J. Basaraba, Thomas Meersmann,

Advanced MRI Techniques and Applications

For the first time, magnetic resonance imaging (MRI) with hyperpolarized (hp) krypton-83 ( 83 Kr) has become available. The relaxation of the nuclear spin of 83 Kr atoms ( I = 9/2) is driven by quadrupolar interactions during brief adsorption periods on surrounding material interfaces. Experiments in model systems reveal that the longitudinal relaxation of hp 83 Kr gas strongly depends on the chemical composition of the materials. The relaxation-weighted contrast in hp 83 Kr MRI allows for the distinction between hydrophobic and hydrophilic surfaces. The feasibility of hp 83 Kr MRI of airways is tested in canine lung tissue by using krypton gas with natural abundance isotopic distribution. Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated.