The peptide-binding strategy of the MHC class II I-A molecules
1998; Elsevier BV; Volume: 19; Issue: 5 Linguagem: Inglês
10.1016/s0167-5699(97)01238-3
ISSN1355-8242
AutoresBoris Reizis, Miriam Eisenstein, Felix Mor, Irun R. Cohen,
Tópico(s)Immunotherapy and Immune Responses
ResumoDespite the importance of murine major histocompatibility complex (MHC) class II I-A molecules for immunological research, the overall peptide-binding specificities of I-A and the homologous human HLA-DQ molecules remain unresolved. Here, Boris Reizis and colleagues review current evidence suggesting that DQ/I-A molecules bind peptides with a different hierarchy of anchor positions than has been found in the well-characterized DR/I-E proteins.
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