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Myelofibrosis with Myeloid Metaplasia in Survivors of the Atomic Bomb in Hiroshima

1964; American College of Physicians; Volume: 60; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-60-1-1

1539-3704

Robert E. Anderson,

Acute Myeloid Leukemia Research

Article1 January 1964Myelofibrosis with Myeloid Metaplasia in Survivors of the Atomic Bomb in HiroshimaROBERT E. ANDERSON, M.D., TAKASHI HOSHINO, M.D., TSUTOMU YAMAMOTO, M.D.ROBERT E. ANDERSON, M.D.Search for more papers by this author, TAKASHI HOSHINO, M.D.Search for more papers by this author, TSUTOMU YAMAMOTO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIdiopathic generalized myelofibrosis with myeloid metaplasia is a disease of unknown etiology in which the clinical and morphologic manifestations vary greatly even during the course of an individual case. The resulting confusion has led to an undue number of synonyms, each of which tends to focus on a single aspect of the disease. Many cases exhibit panhyperplasia of all bone marrow elements including fibroblasts, although eventually the more characteristic picture of fibrosis may predominate. Myeloid metaplasia is a constant and persistent finding, even when the bone marrow is hypercellular. A leukoerythroblastic peripheral blood picture is usually present at some time...References1. OUGHTERSONWARREN AWS, Editors: Medical Effects of the Atomic Bomb in Japan, 1st Ed., McGraw-Hill, New York, 1956, p. 86. Google Scholar2. CRONKITEBONDDURHAM EPVPCL, Editors: Some Effects of Ionizing Radiation on Human Beings. TID-5358, United States Atomic Energy Commission, 1956. Google Scholar3. ARAKAWA ET: Radiation Dosimitry in Hiroshima and Nagasaki Atomic Bomb Survivors. Atomic Bomb Casualty Commission TR 14-59. Google Scholar4. RITCHIEHURST RHGH: Penetration of weapons radiation: application to the Hiroshima-Nagasaki studies. Health Phys. 1: 390, 1959. CrossrefMedlineGoogle Scholar5. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hiroshima,From the Departments of Pathology and Medicine, Atomic Bomb Casualty Commission, Hiroshima, Japan, a research agency of the United States National Academy of Sciences—National Research Council.The work was supported by a grant from the United States Atomic Energy Commission administered in cooperation with the Japanese National Institute of Health of the Ministry of Health and Welfare.Requests for reprints should be addressed to Robert E. Anderson, M.D., Pathologist, Atomic Bomb Casualty Commission, Hijiyama Park, Hiroshima,Japan. 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ANDERSON, M.D., KENZO ISHIDA, M.D.Specificity of the Philadelphia Chromosome Cytogenic Studies in Cases of Chronic Myelocytic Leukemia and Myeloid MetaplasiaKONG-OO GOH, M.D., SCOTT N. SWISHER, M.D., F.A.C.P. 1 January 1964Volume 60, Issue 1Page: 1-18KeywordsBloodBone marrowEtiologyFibroblastsFibrosis ePublished: 1 December 2008 Issue Published: 1 January 1964 Copyright & PermissionsCopyright ©, 1964, by The American College of PhysiciansPDF downloadLoading ...