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Survival after cystectomy for invasive bladder cancer

2010; Elsevier BV; Volume: 36; Issue: 3 Linguagem: Inglês

10.1016/j.ejso.2009.11.012

1532-2157

R.R. de Vries, Jakko A. Nieuwenhuijzen, Alexandra Vincent, Harm van Tinteren, Simon Horenblas,

Urinary and Genital Oncology Studies

AimTo determine the difference in survival after cystectomy between patients presenting with primary muscle infiltrating bladder cancer and patients with progression to muscle infiltration after treatment for initial non muscle invasive bladder cancer (NMIBC). Patients and MethodsWe retrospectively analyzed the files of 188 patients who underwent cystectomy for transitional cell carcinoma between 1987 -2005.Two groups were defined: patients presenting with muscle invasive tumours and those progressing to muscle invasion after initial treatment.This second group was further divided into low-intermediate and high risk according to the EAU grouping for NMIBC. ResultsThe 5-year disease specific survival (95% confidence intervals) for all patients was 50%(42%-59%); 49%(40%-60%) in the primary muscle infiltrating group and 52%(37%-74%) in the progressive group (p=ns).The 5-year disease specific survival in the progressive group according to EAU risk groups was 75%(58%-97%) for the initially diagnosed low-intermediate risk tumours and 35%(17%-71%) for the initially diagnosed high risk tumours (p= 0.015).The percentage of patients with non-locally confined tumours (pT3/4-N0 // any pT-N+) was 31% // 45% and 24% // 46% in the primary muscle infiltrating and progressive group, respectively.