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Absorption of foreign compounds from the gingival sulcus of the rabbit

1979; Elsevier BV; Volume: 24; Issue: 6 Linguagem: Inglês

10.1016/0003-9969(79)90002-5

1879-1506

J.C. Kusek, A.D. Steinberg,

Pharmacological Effects and Toxicity Studies

The disposition of [14C]-phenytoin,125I-bovine serum albumin (BSA) and acid-soluble iodinated by-products of BSA in the gingival sulcus and adjacent soft tissues was monitored. Phenytoin (a low mol. wt, lipid-soluble compound) and BSA (a high mol. wt, water-soluble substance) exhibited similar rates of mobilization (2–8 per cent in 15min) from isotope, impregnated inserts placed within the sulci. Recovery of phenytoin in the sulcular tissue (46 per cent of the amount mobilized) was significantly greater than that of BSA (3–9 per cent). Phenytoin had a greater affinity for sulcular epithelium than BSA, which appeared to concentrate in the connective tissue. The acid-soluble label was readily mobilized (31–57 per cent in 15 min), poorly recovered in the sulcular tissue (3–7 per cent of the amount mobilized) and distributed equally between epithelium and connective tissue.