Synthesis of Renin Inhibitors Containing a Sulfonemethylene Isostere at Their N -Terminals
1990; Oxford University Press; Volume: 19; Issue: 4 Linguagem: Inglês
10.1246/cl.1990.505
ISSN1348-0715
AutoresMasato Nakano, S. ATSUUMI, Yutaka Koike, Seiichi Tanaka, Hiroshi Funabashi, Junko Hashimoto, Mitsuru Ohkubo, Hajime Morishima,
Tópico(s)Synthesis and Catalytic Reactions
ResumoAbstract We describe an efficient synthesis of highly active renin inhibitors containing a sulfonemethylene isostere at their N-terminals and a hydroxyethylene isostere at their C-terminals. The stereospecific synthesis of N-terminal key intermediate, L-N-[(2R)-2-benzyl(or 1-naphthylmethyl)-3-hydroxypropionyl]norleucine t-butyl ester is described.
Referência(s)