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Insecticidal, Anti-juvenile Hormone, and Fungicidal Activities of Organic Extracts from Different Penicillium Species and Their Isolated Active Components

1999; American Chemical Society; Volume: 47; Issue: 5 Linguagem: Inglês

10.1021/jf981010a

1520-5118

María Ángeles Castillo, Pilar Moya, Ángel Cantı́n, Miguel A. Miranda, Jaime Primo, Enrique Hernández‐Orallo, Eduardo Primo‐Yúfera,

Plant tissue culture and regeneration

Organic extracts from mycelium and culture broth of 21 Penicillium isolates have been tested for insecticidal, insect anti-juvenile hormone (anti-JH), and antifungal activities. Culture broth extracts were the most active, mainly against insects; nearly 25% of them have shown high entomotoxicity (100% mortality at 100 microg/cm(2)). A strong in vivo anti-JH activity against Oncopeltus fasciatus Dallas was detected in the culture broth extracts from P. brevicompactum P79 and P88 isolates. The two new natural products isolated from P79, N-(2-methyl-3-oxodec-8-enoyl)-2-pyrroline (1) and 2-hept-5-enyl-3-methyl-4-oxo-6,7,8,8a-tetrahydro-4H-pyrrolo[2,1-b]-1, 3-oxazine (2), possessed anti-JH and insecticidal activity, respectively, against O. fasciatus. Synthesized natural compound 1 has shown an ED(50) of 0.7 microg/nymph when assayed on newly molted fourth-instar nymphs of O. fasciatus. Promising biological activities have also been detected in the synthetic precursors.