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Amides from Piper as a Diuretic: Behind the Ethnopharmacological Uses of Piper glabratum Kunth

2014; Hindawi Publishing Corporation; Volume: 2014; Issue: 1 Linguagem: Inglês

10.1155/2014/615109

1741-4288

Thiago Bruno Lima Prando, Tatiane da Fonseca Baciquete, Jennifer Alexandra Castanho Vieira, Jaqueline Bressan, Francielly Mourão Gasparotto, Douglas Rossi Jesus, Euclides Lara Cardozo, Emerson Luiz Botelho Lourenço, Arquimedes Gasparotto,

Traditional and Medicinal Uses of Annonaceae

Several species of the genus Piper are known in Brazilian folk medicine as having diuretic activity. So, we propose to investigate the acute diuretic activity and the possible toxic effects of Piper glabratum Kunth, popularly known as false Jaborandi. Additionally, we propose to check whether there is any correlation between the biological activities of the crude extract (MEPG) and its 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl-pyrrolidine (MMCP) in Wistar rats. The MEPG was fractioned by chromatography column and the MMCP was identified by analyses of (1)H and (13)C RMN spectral data and correlations. Both MEPG and MMCP were assayed for diuretic activity. The preparations obtained were orally administered in a single dose to rats. The urine excretion, pH, density, conductivity, and content of Na(+), K(+), Cl(-), and HCO3 (-) were measured in the urine of saline-loaded animals. Additionally, acute toxicity of the extract was also evaluated. MMCP at doses of 30 mg/kg was able to increase the urine volume, pH, and HCO3 (-) excretion. Moreover, high dosage of MEPG showed important liver toxicity and elevated mortality when injected intraperitoneally. The results indicate that the MMCP shows important diuretic properties when administered in Wistar rats. Additionally, MEPG can induce important acute toxicity if given in high doses.