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Acquired immune suppression and other risk factors/indicators for periodontal disease progression

2003; Wiley; Volume: 32; Issue: 1 Linguagem: Inglês

10.1046/j.0906-6713.2003.03210.x

1600-0757

Thomas W. Stanford, Terry D. Rees,

Oral Health Pathology and Treatment

Periodontology 2000Volume 32, Issue 1 p. 118-135 Acquired immune suppression and other risk factors/indicators for periodontal disease progression Thomas W. Stanford, Thomas W. StanfordSearch for more papers by this authorTerry D. Rees, Terry D. ReesSearch for more papers by this author Thomas W. Stanford, Thomas W. StanfordSearch for more papers by this authorTerry D. Rees, Terry D. ReesSearch for more papers by this author First published: 20 May 2003 https://doi.org/10.1046/j.0906-6713.2003.03210.xCitations: 24Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Abdellatif HM, Burt BA. An epidemiological investigation into the relative importance of age and oral hygiene status as determinants of periodontitis. J Dent Res 1987: 66: 13–18. 2 Agren M, Stromberg H, Rindby A, Hallmans G. Selenium, zinc, iron and copper levels in serum of patients with arterial and venous leg ulcers. Acta Derm Venereol 1986: 66: 237–240. 3 Ajwani S, Ainamo A. Periodontal conditions among the old elderly: five-year longitudinal study. Spec Care Dentist 2001: 21: 45–51. 4 Albandar JM. A 6-year study on the pattern of periodontal disease progression. J Clin Periodontol 1990: 17: 467–471. 5 Alfano MC. Controversies, perspectives and clinical implications of nutrition in periodontal disease. Dent Clin North Am 1976: 20: 519–548. 6 Altman LC, Baker C, Fleckman P, Luchtel D, Oda D. Neutrophil-mediated damage to human gingival epithelial cells. J Periodontal Res 1992: 27: 70–79. 7 Alvares O, Siegel I. Permeability of gingival sulcular epithelium in development of scorbutic gingivitis. J Oral Pathol 1981: 10: 40–48. 8 Ammatuna P, Campisi G, Giovannelli L, Giambelluca D, Alaimo C, Mancuso S, Margiotta V. Presence of Epstein-Barr virus, cytomegalovirus and human papillomavirus in normal oral mucosa of HIV-infected and renal transplant patients. Oral Dis 2001: 7: 34–40. 9 Andres E, Kurtz JE, Perrin AE, Maloisel F, Demangeat C, Goichot B, Schlienger JL. Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption. Am J Med 2001: 111: 126–129. 10 Aseni P, Vertemati M, Minola E, Arcieri K, Bonacina E, Camozzi M, Osio C, Forti D. Kaposi's sarcoma in liver transplant recipients: morphological and clinical description. Liver Transpl 2001: 7: 816–823. 11 Asman B. Peripheral PMN cells in juvenile periodontitis. Increased release of elastase and oxygen radicals after stimulation with opsonized bacteria. J Clin Periodontol 1988: 153: 360–366. 12 Ausman B, Wijkander P, Hjerpe A. Reduction of collagen degradation in experimental granulation tissue by vitamin E and selenium. J Clin Periodontol 1994: 21: 45–47. 13 Axteliuus B, Soderfeldt B, Nilsson A, Edwardson S, Attstrom R. Therapy-resistant periodontitis, psychosocial characteristics. J Clin Periodontol 1998: 25: 482–491. 14 Baelum V, Luan WM, Chen X, Fejerskov O. A 10-year study of the progression of destructive periodontal disease in adult and elderly Chinese. J Periodontol 1997: 68: 1033–1053. 15 Baker E, Crook G, Schwabacher E. Personality correlates of periodontal disease. J Dent Res 1961: 40: 396–403. 16 Ballieux R. Impact of mental stress on the immune response. J Clin Periodontol 1991: 18: 427–430. 17 Baqui A, Meiller T, Jabra-Rizk M, Zhang M, Kelley J, Falkler W. Association of HIV viral load with oral diseases. Oral Dis 1999: 5: 294–298. 18 Barr C, Lopez MR, Rua-Dobles A. Periodontal changes by HIV serostatus in a cohort of homosexual and bisexual men. J Clin Periodontol 1992: 19: 794–801. 19 Bartold PM, Kylstra A, Lawson R. Substance P: An immunohistochemical and biochemical study in human gingival tissues. A role for neurogenic inflammation? J Periodontol 1994: 65: 1113–1121. 20 Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: The challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999: 10: 458–476. 21 Beck JD. Periodontal implications: older adults. Ann Periodontol 1996: 1: 322–357. 22 Beck JD, Koch GG. Incidence of attachment loss over 3 years in older adults – new and progressing lesions. Community Dent Oral Epidemiol 1995: 23: 291–296. 23 Becker BC, Karp CL, Becker W, Berg L. Personality differences and stressful life events. Differences between treated periodontal patients with and without maintenance. J Clin Periodontol 1988: 15: 49–52. 24 Belting CM. A review of the epidemiology of periodontal diseases. J Periodontol 1957: 28: 37–46. 25 Binkley NC, Suttie JW. Vitamin K nutrition and osteoporosis. J Nutr 1995: 125: 1812–1821. 26 Bissada N, Demarco J. The effect of a hypocalcemic diet on the periodontal structure of the adult rat. J Periodontol 1974: 45: 739–745. 27 Boyar RM. Anorexia nervosa. In: KJ Isselbacker, ed. Principles of Internal Medicine, 9th edn. New York: McGraw-Hill, 1980: 416–418. 28 Boyle PE. Effect of vitamin A deficiency on the periodontal tissues. Am J Orthod 1947: 33: 744–748. 29 Bozkurt FY, Berker E, Akkus S, Bulut S. Relationship between interleukin-6 levels in gingival crevicular fluid and periodontal status in patients with rheumatoid arthritis and adult periodontitis. J Periodontol 2000: 71: 1756–1760. 30 Breivik T, Opstad PK, Gjermo P, Thrane PS. Effects of hypothalamic-pituitary-adrenal axis reactivity on periodontal tissue destruction in rats. Eur J Oral Sci 2000: 108: 115–122. 31 Breivik T, Sluyyter R, Hof M, Cools A. Differential susceptibility to periodontitis in genetically selected Wistar rat lines that differ in their behavioral and endocrinologic response to stressors. Behav Genet 2000: 30: 123–130. 32 Breivik T, Thrane PS, Murison R, Gjermo P. Emotional stress effects on immunity, gingivitis and periodontitis. Eur J Oral Sci 1996: 104: 327–334. 33 Brown LF, Beck JD, Rozier RG. Incidence of attachment loss in community-dwelling older adults. J Periodontol 1994: 65: 316–323. 34 Brown R, DiaStanislau P, Beaver W, Bottomley W. The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. Oral Surg Oral Med Oral Pathol 1991: 71: 565–568. 35 Burt BA. Periodontitis and aging: reviewing recent evidence. J Am Dent Assoc 1994: 125: 273–279. 36 Bustos DA, Grenon MS, Benitez M, De Boccardo G, Pavan JV, Gendelman H. Human papillomavirus infection in cyclosporin-induced gingival overgrowth in renal allograft recipients. J Periodontol 2001: 72: 741–744. 37 Carranza FA Jr, Cabrini RL, Lopez OR. Histometric analysis of interradicular bone in protein deficient animals. J Periodontal Res 1969: 4: 292–295. 38 Ceballos-Salobrena A, Gaitan-Cepeda LA, Ceballos-Garcia L, Lezama-Del Valle D. Oral lesions in HIV/AIDS patients undergoing highly active antiretroviral treatment including protease inhibitors: a new face of oral AIDS? AIDS Patient Care STDS 2000: 14: 627–635. 39 Celenligil H, Eratalay K, Kansu E, Ebersole JL. Periodontal status and serum antibody responses to oral microorganisms in Sjogren's syndrome. J Periodontol 1998: 69: 571–577. 40 Charbeneau TD, Hurt WC. Gingival findings in spontaneous scurvy. J Periodontol 1983: 54: 694–697. 41 Chatterton RT, Vogelsong KM, Lu Y-C, Hudgens GA. Hormonal responses to psychological stress in men preparing for skydiving. J Clin Endocrinol Metab 1997: 82: 2503–2509. 42 Chawla TN, Glickman I. Protein deprivation and the periodontal structures of the albino rat. Oral Surg 1951: 4: 578–602. 43 Cheraskin E, Ringsdorf J, Setyaadmadija A, Ray D. An ecologic analysis of gingival state: Effect of prophylaxis and protein supplementation. J Periodontol 1968: 39: 316–321. 44 Cheraskin E, Ringsdorf J, Setyaadmadija A, Ray D. An ecologic analysis of tooth mobility: Effect of prophylaxis and protein supplementation. J Periodontol 1967: 38: 227–236. 45 Chu FC, Tsang PC, Chan AW, Leung WK, Samaranayake LP, Chan TM. Oral health status, oral microflora, and non-surgical periodontal treatment of renal transplant patients receiving cyclosporin A and FK506. Ann R Australas Coll Dent Surg 2000: 15: 286–291. 46 Cogen R, Stevens AW Jr, Cohen-Cole S, Kirk K, Freeman A. Leukocte function in the etiology of acute necrotizing ulcerative gingivitis. J Periodontol 1983: 54: 492–407. 47 Cohen M, Shusterman S, Shklar G. The effect of stressor agents on the gray lethal mouse strain periodontium. J Periodontol 1969: 40: 462–466. 48 Cohen-Cole SA, Cogen RB, Stevens AW Jr, Kirk K, Gaitan E, Bird J, Cooksey R, Freeman A. Psychiatric, psychosocial, and endocrine correlates of acute necrotizing ulcerative gingivitis (trench mouth): a preliminary report. Psychiatr Med 1983: 1: 215–220. 49 Contreras A, Mardirossian A, Slots J. Herpesviruses in HIV-periodontitis. J Clin Periodontol 2001: 28: 96–102. 50 Croucher R, Marcenes WS, Torres MC, Hughes F, Sheiham A. The relationship between life-events and periodontitis. A case-control study. J Clin Periodontol 1997: 24: 39–43. 51 Cutler CW, Shinedling EA, Nunn M, Jotwani R, Kim BO, Nares S, Iacopino AM. Association between periodontitis and hyperlipidemia: Cause or effect? J Periodontol 1999: 70: 1429–1434. 52 Davis JM, Albert JD, Tracy KJ, Calvano SE, Lowry SF, Shires GT, Yurt RW. Increased neutrophil mobilization and decreased chemotaxis during cortisol and epinephrine infusions. J Trauma 1991: 31: 725–732. 53 Davis R, Baer P. Necrotizing ulcerative gingivitis in drug addict patients being withdrawn from drugs. Oral Surg Oral Med Oral Pathol 1971: 31: 200–204. 54 Dean MT, Dean RD. Gingival symptom complexes. Am J Orthodont Oral Surg 1945: 31: 473–486. 55 Deinzer R, Forster P, Fuck L, Herforth A, Stiller-Winkler R, Idel H. Increase of crevicular interleukin 1 beta under academic stress at experimental gingivitis sites and at sites of perfect oral hygiene. J Clin Periodontol 1999: 26: 1–8. 56 Deinzer R, Hilpert D, Bach K, Schawacht M, Herforth A. Effects of academic stress on oral hygiene – a potential link between stress and plaque-associated disease? J Clin Periodontol 2001: 28: 459–464. 57 Deinzer R, Kleineidam C, Stiller-Winkler R, Idel H, Bachg D. Prolonged reduction of salivary immunoglobulin A (SIgA) after a major academic exam. Int J Psychophysiol 2000: 37: 219–232. 58 Deinzer R, Kottmann W, Forster P, Herforth A, Stiller-Winkler R, Idel H. After-effects of stress on crevicular interleukin-1 beta. J Clin Periodontol 2000: 27: 74–77. 59 Deinzer R, Rutterman S, Mobes O, Herforth A. Increase in gingival inflammation under academic stress. J Clin Periodontol 1998: 25: 431–433. 60 De Maar EF, Verschuuren EA, Homan vd Heide JJ, Kas-Deelen DM, Jagenath D, The TH, Ploeg RJ, Van Son WJ. Effects of changing immunosuppressive regimen on the incidence, duration, and viral load of cytomegalovirus infection in renal transplantation: a single center report. Transpl Infect Dis 2002: 4: 17–24. 61 De Marco T. Periodontal emotional stress syndrome. J Periodontol 1960: 47: 67–68. 62 De Menezes AC, Costa IM, El-Guindy MM. Clinical manifestations of hypervitaminosis A in human gingiva. A case report. J Periodontol 1984: 55: 474–476. 63 Doxley DL, Cutler CW, Iacopino AM. Diabetes prevents periodontitis-induced increases in gingival platelet derived growth factor-B and interleukin 1-beta in a rat model. J Periodontol 1998: 69: 113–119. 64 Dreizen S, Levy B, Bernick S. Studies on the biology of the periodontium of marmosets. XI. Histopathologic manifestations of spontaneous and induced vitamin A deficiency in the oral structures of adult marmosets. J Dent Res 1973: 52: 803–809. 65 Drinkard CR, Decher L, Little JW, Rhame F, Balfour HH Jr, Rhodus NL, Merry JW, Walker PO, Miller CE, Volberding PA. Periodontal status of individuals in early stages of immunodeficiency virus infection. Community Dent Oral Epidemiol 1991: 19: 281–285. 66 Eklund S, Burt. Risk factors for tooth loss in the United States: Longitudinal analysis of national data. J Public Health Dent 1994: 54: 5–14. 67 Ellen RP. Periodontal disease among older adults: what is the issue? Periodontol 2000 1998: 16: 7–8. 68 Elter JR, Williams RC, Champagne CME, Offenbacher S, Beck JD. Association of obesity and periodontitis. J Dent Res 2000: 79 (Spec iss): 625 [abstract 3855]. 69 Enwonwu CO. Cellular and molecular effects of malnutrition and their relevance to periodontal disease. J Clin Periodontol 1994: 21: 643–657. 70 Enwonwu C. Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. Arch Oral Biol 1972: 17: 1357–1371. 71 Enwonwu CO. Interface of malnutrition and periodontal diseases. Am J Clin Nut 1995: 61 (Suppl): 430S–436S. 72 Epstein JB, Leziy S, Ransier A. Periodontal pocketing in HIV-associated periodontitis. Spec Care Dent 1993: 13: 236–240. 73 Faddy MJ, Cullinan MP, Palmer JE, Westerman B, Seymour GJ. Ante-dependence modeling in a longitudinal study of periodontal disease: The effect of age, gender, and smoking status. J Periodontol 2000: 71: 454–459. 74 Falconer DT. Scurvy presenting with oral symptoms. Br Dent J 1979: 146: 313–314. 75 Field EA, Speechley JA, Rugman FR, Varga E, Tyldesly WR. Oral signs and symptoms in patients with undiagnosed vitamin B12 deficiency. J Oral Pathol Med 1995: 24: 468–470. 76 Finegold KR, Staprans I, Memon RA, Moser AH, Shigenaga JK, Doerrler W, Dirarello CA, Grunfeld C. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res 1992: 33: 1765–1766. 77 Flemmig TF, Shanahan F, Miyasaki KT. Prevalence and severity of periodontal disease in patients with inflammatory bowel disease. J Clin Periodontol 1991: 18: 690–697. 78 Formicola A, Witte E, Curran P. A study of personality traits and acute necrotizing ulcerative gingivitis. J Periodontol 1970: 41: 36–38. 79 Frandsen AM. Periodontal tissue changes in vitamin A deficiency in young rats. Acta Odontol Scand 1963: 21: 19–34. 80 Frandsen A, Becks H, Nelson M, Evans H. The effects of various levels of dietary protein on the periodontal tissues of young rats. J Periodontol 1953: 24: 135–142. 81 Freeland JH, Cousins RJ, Schwartz R. Relationship of mineral status and intake to periodontal disease. Am J Clin Nutr 1976: 29: 745–749. 82 Freeman R: Goss S. Stress measures as predictors of periodontal disease-a preliminary communication. Community Dent Oral Epidemiol 1993: 21: 176–177. 83 Friedlander A:, West L. Dental management of the patient with major depression. Oral Surg Oral Med Oral Pathol 1991: 71: 573–578. 84 Friedman RB, Gunsolley J, Gentry A, Dinius A, Kaplowitz L, Settle J. Periodontal status of HIV seropositive and AIDS patients. J Periodontol 1991: 62: 623–677. 85 Galgut PN, Waite IM, Todd-Polropek A, Barnby GJ. The relationship between multidimensional health locus of control and the performance of subjects on a preventive periodontal programme. J Clin Periodontol 1987: 14: 171–175. 86 Garewal H, Meyskens JF, Friedman S, Alberts D, Ramsey L. Oral cancer prevention: The case for carotenoids and anti-oxidant nutrients. Prev Med 1993: 22: 701–711. 87 Genco RL Ho AW, Grossi SG, Dunford RG, Tedesco LA. Relationship of stress, distress and inadequate coping behaviors to periodontal disease. J Periodontol 1999: 70: 711–723. 88 Giddon D, Goldhaber P, Dunning J. Prevalence of reported cases of acute necrotizing ulcerative gingivitis in a university population. J Periodontol 1963: 34: 366–371. 89 Gleissner C, Willerhausen B, Kasser U, Bolten WW. The role of risk factors for periodontal disease in patients with rheumatoid arthritis. Eur J Med Res 1998: 18: 387–392. 90 Glick M, Holmstrup P. HIV infection and periodontal diseases. In: LF Rose, RJ Genco, Mealey BL, DW Cohen, eds. Periodontal medicine, 1st edn, Chapter 11. Hamilton: BC Decker, 2000. 91 Gornitsky M, Clark DC, Siboo R, Amsel R, Iugovaz I, Wooley C, Iuliani N, Chan EC. Clinical documentation and occurrence of putative periodontopathic bacteria in human immunodeficiency virus-associated periodontal disease. J Periodontol 1991: 62: 576–585. 92 Grbic JT, Lamster IB. Risk indicators for future clinical attachment loss in adult periodontitis. Tooth and site variables. J Periodontol 1992: 63: 262–269. 93 Grbic JT, Lamster IB, Celenti RS, Fine JB. Risk indicators for future clinical attachment loss in adult periodontitis: patient variables. J Periodontol 1991: 62: 322–329. 94 Green L, Tryon WB, Huryn J. Periodontal disease as a function of life events stress. J Human Stress 1986: 12: 32–36. 95 Greenwood AM, O'Reilly R, O'Riordan WJ, Linden GJ. The oral and dental manifestations of bulimia nervosa compared with those of anorexia nervosa. J Ir Dent Assoc 1988: 34: 26–28. 96 Grossi SG, Genco RJ, Machtei EE, Ho AW, Koch G, Dunford R, Zambon JJ, Hausmann E. Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. J Periodontol 1995: 66: 23–29. 97 Grossi SG, Ho AW. Obesity, insulin resistance and periodontal disease (abstract). J Dent Res 2000: 79(Spec iss): 625 [Abstract A-3854]. 98 Grossi S. Zambon JJ, Ho AW, Koch G, Dunford RG, Machtei EE, Norderyn OM, Genco RJ. Assessment of risk for periodontal disease. 1. Risk indicators for attachment loss. J Periodontol 1994: 65: 260–267. 99 Grupe H, Wilder L. Observations of necrotizing gingivitis in 870 miliatry trainees. J Periodontol 1956: 45: 255–266. 100 Gupta OP. Psychosomatic factors in periodontal disease. Dent Clin North Am 1966: Mar: 11–19. 101 Gupta OP. Psychosomatic factors in periodontal disease. J Indian Dent Assoc 1968: 40: 101–107. 102 Gupta O, Blechman H, Stahl S. Effects of stress on the periodontal tissues of young adult male rats and hamsters. J Periodontol 1960: 31: 413–417. 103 Gyorfi A, Fazekas A, Suba Zs, Ender F, Rosivall L. Neurogenic component in ligature-induced periodontitis in the rat. J Clin Periodontol 1994: 21: 601–605. 104 Haffajee A, Socransky SS, Lindhe J, Kent RL, Okamoto H, Yoneyama T. Clinical risk indicators for periodontal attachment loss. J Clin Periodontol 1991: 18: 117–125. 105 Hansen M, Fernandes G, Good R. Nutrition and immunity: The influence of diet on autoimmunity and the role of zinc in the immune response. Ann Rev Nutr 1982: 2: 151–177. 106 Haskell B. Association of aircraft noise to periodontal disease in aircrew members. Aviat Space Environ Med 1975: 46: 1041–1043. 107 Hendler BH, Steinberg BJ, Brown S. Dental correlations. In: LF Rose, D Kaye, eds. Internal medicine for dentistry. St. Louis: Mosby, 1983: 1090–1113. 108 Hennekens C, Buring J. Antioxidant vitamins - benefits not yet proven. New Engl J Med 1994: 330: 1080–1081. 109 Hildebrand HC, Epstein J, Larjava H. The influence of psychological stress on periodontal disease. Periodontal Abstr 2000: 48: 69–77. 110 Hoos KA. Drug-induced gingival hyperplasia in transplant recipients. Prog Transplant 2002: 12: 17–21. 111 Horning GM, Cohen ME. Necrotizing ulcerative gingivitis, periodontitis and stomatitis: clinical staging and predisposing factors. J Periodontol 1995: 66: 990–998. 112 Hugoson A, Ljungquist B, Breivik T. Ther relationship of some negative events and psychological factors to periodontal disease in an adult Swedish population 50 to 80 years of age. J Clin Periodontol 2002: 29: 247–253. 113 Iacopino AM. Periodontitis and diabetes interrelationships: role of inflammation. Ann Periodontol 2001: 6: 125–137. 114 Ismail AL, Burt BA, Eklund SA. Epidemiologic patterns of smoking and periodontal disease in the United States. J Am Dent Assoc 1983: 106: 617–623. 115 Ismail A, Burt A, Eklund S. Relation between ascorbic acid intake and periodontal disease in the United States. J Am Dent Assoc 1983: 107: 927–931. 116 Ismail AL, Morrison EC, Burt BA, Caffesse RG, Kavanagh MT. Natural history of periodontal disease in adults: findings from the Tecumseh Periodontal Disease Study, 1959-87. J Dent Res 1990: 69: 430–435. 117 James JA, Jamal S, Hull PS, Macfarlane TV, Campbell BA, Johnson RW, Short CD. Tacrolimus is not associated with gingival overgrowth in renal transplant patients. J Clin Periodontol 2001: 28: 848–852. 118 Jensen OE, Featherstone JD, Stege P. Chemical and physical oral findings in a case of anorexia nervosa and bulimia. J Oral Pathol 1987: 16: 399–402. 119 Johnson B, Engel D. Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment. J Periodontol 1986: 57: 141–149. 120 Joseph C, Asgrafi S, Steinberg A, Waterhouse J. Zinc deficiency changes in the permeability of rabbit periodontium to c-phenytoin and c-albumin. J Periodontol 1981: 53: 251–256. 121 Kasser UR, Gleissner C, Dehne F, Michel A, Willershausen-Zonnchen B, Bolten WW. Risk for periodontal disease in patients with longstanding rheumatoid arthritis. Arthritis Rheum 1997: 40: 2248–2251. 122 Katz J, Chaushu G, Sharabi Y. On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. J Clin Periodontol 2001: 28: 865–868. 123 Katz J, Flugelman MY, Goldberg A, Heft M. Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 2002: 73: 494–500. 124 Khocht A, Schneider LC. Periodontal management of gingival overgrowth in the heart transplant patient: a case report. J Periodontol 1998: 69: 1314–1315. 125 Khongkunthian P, Grote M, Isaratanan W, Piyaworawong S, Riechart PA. Oral manifestations in 45 HIV-positive children from Northern Thailand. J Oral Pathol Med 2001: 30: 549–552. 126 Khongkunthian P, Grote M, Isaratanan W, Piyaworawong S, Riechart PA. Oral manifestations in HIV-positive adults from Northern Thailand. J Oral Pathol Med 2001: 30: 220–223. 127 Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R. Slowing of wound healing by psychological stress. Lancet 1995: 346: 1194–1196. 128 Klokevold PR, Mealy BL, Carranza FA. Influence of systemic disease and disorders on the periodontium. In: MG Newman, HH Takei, FA Carranza, eds. Clinical periodontology, 9th edn. Philadelphia: Saunders, 2002: 204–228. 129 Kopelman PG. Obesity as a medical problem. Nature 2000: 404: 635–643. 130 Kornman KS. The epidemiology of periodontal diseases. In: TG Wilson, KS Kornman, eds. Fundamentals of periodontics, 1st edn. Chicago: Quintessence, 1996: 9–16. 131 Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med 2001: 111: 452–456. 132 Lamey P-J, Linden GJ, Freeman R. Mental disorders and periodontics. Periodontol 2000 1998: 18: 71–80. 133 Landa J. Psychosomatics in relation to periodontics. J Periodontol 1954: 25: 209–215. 134 Laufer D, Benderly A, Hochberg Z. Dental pathology in calcitriol resistant rickets. J Oral Med 1987: 42: 272–275. 135 Leggott P, Robertson P, Rothman D, Murray P, Jacob R. The effect of controlled ascorbic acid depletion and supplementation on periodontal health. J Periodontol 1986: 57: 480–485. 136 LeResche L, Dwrkin SF. The role of stress in inflammatory disease, including periodontal diseases: review of concepts and current findings. Periodontol 2000 2002: 30: 91–103. 137 Locker D, Leake JL. Risk indicators and risk markers for periodontal disease experience in older adults living independently in Ontario, Canada. J Dent Res 1993 72: 9–17. 138 Locker D, Slade GD, Murray H. Epidemiology of periodontal disease among older adults: a review. Periodontol 2000 1998: 16: 16–33. 139 Loesche WJ. Importance of nutrition in gingival crevice microbial ecology. Periodontics 1968: 6: 245–249. 140 Loesche WJ, Karapetow F, Pohl A, Pohl C, Kocher T. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J Clin Periodontol 2000: 27: 537–541. 141 Loesche WJ, Syed SA, Laughon BE, Stoll J. The bacteriology of acute necrotizing ulcerative gingivitis. J Periodontol 1982: 53: 223–230. 142 Lorato DC. Oral tissue changes in the chronic alcoholic. J Periodontol 1972: 43: 772–773. 143 Maddox JF, Aherne KM, Reddy CC, Sordillo LM. Increased neutrophil adherence and adhesion molocule mRNA expression in endothelial cells during selenium deficiency. J Leukoc Biol 1999: 65: 658–664. 144 Magalhaes MG, Bueno DF, Serra E, Goncalves R. Oral manifestations of HIV positive children. J Clin Pediatr Dent 2001: 25: 103–106. 145 Manhold J. Report of a study on the relationship of personality variables to periodontal conditions. J Periodontol 1953: 24: 248–251. 146 Mardirossian A, Contreras A, Navazesh M, Nowzari H, Slots J. Herpesviruses 6,7 and 8 in HIV- and non-HIV-associated periodontitis. J Periodontal Res 2000: 35: 278–284. 147 Marshall-Day CD, Stephens RG, Quigley LFJ. Periodontal disease: prevalence and incidence. J Periodontol 1955: 26: 185–203. 148 Maupin C, Bell B. Relationship of 17-hydroxycorticosteroid to acute necrotizing ulcerative gingivitis. J Periodontol 1975: 46: 721–722. 149 McKaig RG, Patton LL, Thomas JC, Strauss RP, Slade GD, Beck JD. Factors associated with periodontitis in an HIV-infected southeast USA study. Oral Dis 2000: 6: 158–165. 150 McKaig RG, Thomas JC, Patton LL, Strauss RP, Slade GD, Beck JD. Prevalence of HIV-associated periodontitis and chronic periodontitis in a southeastern US study group. J Public Health Dent 1998: 58: 294–300. 151 Mercado F, Marshall RI, Klestov AC, Bartold PM. Is there a relationship between rheumatoid arthritis and periodontal disease? J Clin Periodontol 2000: 27: 267–272. 152 Mercado FB, Marshall RI, Klestov AC, Bartold PM. Relationship between rheumatoid arthritis and periodontitis. J Periodontol 2001: 72: 779–787. 153 Miglani D. The effect of vitamin A deficiency on the periodontal structures of rat molars, with emphasis on cementum resorption. Oral Surg Oral Med Oral Pathol 1954: 12: 1372–1376. 154 Milosevic A. Eating disorders and the dentist. Br Dent J 1999: 186: 109–113. 155 Miller S, Thaller J, Soverman A. The use of the Minnesota multiphasic personality inventory as a diagnostic aid in periodontal disease-preliminary report. J Periodontol 1956: 27: 44–46. 156 Mitchell K, Ferguson M, Lucie N, MacDonald D. Epithelial dysplasia in the oral mucosa associated with pernicious anemia. Br Dent J 1986: 161: 259–260. 157 Monteiro da Silva AM, Newman HN, Oakley DA. Psychosocial factors in inflammatory periodontal diseases. A review. J Clin Periodontol 1995: 22: 516–526. 158 Monteiro da Silva AM, Newman HN, Oakley DA O'Leary R. Psychosocial factors, dental plaque levels and smoking in periodontitis patients. J Clin Periodontol 1998: 25: 517–523. 159 Moss ME, Beck JD, Kaplan BH, Offenbacher S, Weintraub JA, Koch G, Genco RJ, Machtei EE, Tedesco LA. Exploratory case-control analysis of psychosocial factors and adult periodontitis. J Periodontol 1996: 67 (10 Suppl): 1060–1069. 160 Moulton R, Ewen S, Thieman W. Emotional factors in periodontal disease. Oral Surg 1952: 5: 833–837. 161 Murayama Y, Kurihara H, Nagai A, Dompkowski D, Van Dyke TE. Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms. Periodontol 2000 1994: 6: 116–124. 162 Mutlu S, Richards A, Maddison P, Scully C. Gingival and periodontal health in systemic lupus erythematosus. Community Dent Oral Epidemiol 1993: 21: 158–161. 163 Nagler RM, Lorber M, Ben-Arieh Y, Laufer D, Pollack S. Generalized periodontal involvement in a young patient with systemic lupus erythematosus. Lupus 1999: 8: 770–772. 164 Ndiaye CF, Critchlow CW, Leggot PJ, Kiviat NB, Ndoye I, Robertson PB, Georgas KN. Periodontal status of HIV1 and HIV2 seropositive female commercial sex workers in Senegal. J Periodontol 1997: 68: 827–831. 165 Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ. Dietary vitamin C and the risk for periodontal disease. J Peridontol 2000: 71: 1215–1223. 166 Nishida M, Grossi SG, Dunford RG, Ho AW, Trevisan M, Genco RJ. Calcium and the risk for periodontal disease. J Periodontol 2000: 71: 1057–10