Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat
1986; Elsevier BV; Volume: 7; Issue: 3 Linguagem: Inglês
10.1016/0197-4580(86)90046-1
ISSN1558-1497
AutoresAnat Biegon, Varda Greenberger, Menahem Segal,
Tópico(s)Nicotinic Acetylcholine Receptors Study
ResumoUsing a newly developed method for quantitative acetylcholinesterase (AChE) histochemistry we find a substantial decrease in AChE content in aged rats compared to young controls in the cholinergic cell body regions (the ventral pallidum and the medial septal nuclei) and, to a smaller extent in the projection areas (the cortex and hippocampus). In the same group of aged rats we find a severe deficit in the acquisition of a water maze task. Quantitative histochemistry is a potent method for detecting localized changes in AChE content in otherwise intact, learning-impaired aged rats.
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