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FAILURE OF AMINOACETIC ACID TO INCREASE THE WORK CAPACITY OF HUMAN SUBJECTS

1942; American Medical Association; Volume: 118; Issue: 8 Linguagem: Inglês

10.1001/jama.1942.02830080026006

1538-3598

ERNEST Q. KING,

Muscle Physiology and Disorders

During the past decade aminoacetic acid has been used in the treatment of various myopathies and currently is the subject of debate relative to its value in the treatment of fatigue and in increasing endurance. Aminoacetic acid is also known as glycine and glycocoll. It is present in most of the common proteins, and by chemical analyses 1 one fourth of the protein, gelatin, has been shown to be aminoacetic acid. From 1927 to 1929 Brand, Harris, Sandberg and Ringer 2 in their search for the precursor of creatine first gave aminoacetic acid to patients with progressive muscular dystrophy. Thomas, Milhorat and Techner 3 in 1932 reported clinical improvement in certain patients with this disease after prolonged treatment with this amino acid. Brand and his co-workers 4 in their original work, and later in 1933, and Boothby 5 in 1934 failed to find such beneficial effect in patients with progressive