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Prevention of sudden cardiac death: rationale and design of the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) Trial – a prospective pilot study

2008; Taylor & Francis; Volume: 24; Issue: 8 Linguagem: Inglês

10.1185/03007990802237343

1473-4877

Míhàly K. de Bie, Jaco C Lekkerkerker, Bastiaan van Dam, André Gaasbeek, Marjolijn van Buren, Hein Putter, Lieselot van Erven, Jeroen J. Bax, Martin J. Schalij, Ton J. Rabelink, J. Wouter Jukema,

Cardiac Arrhythmias and Treatments

Sudden cardiac (arrhythmic) death (SCD) is the single largest cause of death in dialysis patients. Prophylactic Implantable Cardioverter Defibrillator (ICD) therapy reduces SCD and reduces all-cause mortality in several groups of patients at high risk for arrhythmic death. Whether this also applies to dialysis patients is unknown.The Implantable Cardioverter Defibrillator in Dialysis patients (ICD2) trial is a prospective randomised controlled study. It has been designed to evaluate the efficacy and safety of prophylactic ICD therapy in reducing sudden cardiac death rates in dialysis patients aged 55-80 years. A total of 200 patients will be included. The primary endpoint of the study is sudden cardiac (arrhythmic) death. The mean follow-up time will be 4 years.'The Netherlands Trial Register'--ISRCTN20479861The ICD2 trial--a pilot study--will be the first study to evaluate the possible benefit of ICD therapy for the primary prevention of sudden cardiac death in dialysis patients.