EFFECTS OF CYCLOSPORIN A ON SUPPRESSOR AND INDUCER T LYMPHOCYTES IN PRIMARY BILIARY CIRRHOSIS
1980; Elsevier BV; Volume: 316; Issue: 8206 Linguagem: Inglês
10.1016/s0140-6736(80)92481-2
ISSN1474-547X
AutoresGuitaine Routhier, George Janossy, Owen Epstein, Howard C. Thomas, S. Sherlock, Patrick C. Kung, Gideon Goldstein,
Tópico(s)Liver Disease and Transplantation
ResumoThere is a significant decrease in the ratio of inducer (helper) to suppressor T lymphocytes in the peripheral blood of patients with primary biliary cirrhosis (PBC). These changes are not seen in other forms of cholestatic liver disease, but are similar to those described in chronic graft-versus-host disease. Cyclosporin A treatment increased the proportion of suppressor T lymphocytes and improved liver function in 6 patients with PBC. This indicates that cyclosporin A is an immunoregulatory drug. Unfortunately nephrotoxicity precluded long-term use.
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