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Discovery and Optimization of a Novel Series of Thrombin Receptor (PAR-1) Antagonists: Potent, Selective Peptide Mimetics Based on Indole and Indazole Templates

2001; American Chemical Society; Volume: 44; Issue: 7 Linguagem: Inglês

10.1021/jm000506s

1520-4804

Han‐Cheng Zhang, Claudia K. Derian, Patricia Andrade‐Gordon, William J. Hoekstra, David F. McComsey, Kimberly B. White, Brenda L. Poulter, Marylyn M. Addo, Wai-man Cheung, Bruce P. Damiano, Donna Oksenberg, Elwood E. Reynolds, Anjali Pandey, Robert M. Scarborough, Bruce E. Maryanoff,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery and Optimization of a Novel Series of Thrombin Receptor (PAR-1) Antagonists: Potent, Selective Peptide Mimetics Based on Indole and Indazole Templates†Han-Cheng Zhang, Claudia K. Derian, Patricia Andrade-Gordon, William J. Hoekstra, David F. McComsey, Kimberly B. White, Brenda L. Poulter, Michael F. Addo, Wai-Man Cheung, Bruce P. Damiano, Donna Oksenberg, Elwood E. Reynolds, Anjali Pandey, Robert M. Scarborough, and Bruce E. MaryanoffView Author Information Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, and COR Therapeutics, Inc., South San Francisco, California 94080 Cite this: J. Med. Chem. 2001, 44, 7, 1021–1024Publication Date (Web):March 22, 2001Publication History Received27 November 2000Published online22 March 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/jm000506shttps://doi.org/10.1021/jm000506srapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1142Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aggregation,Antagonists,Assays,Cells,Peptides and proteins Get e-Alerts