Biogenic Amines and the Secretion of Parathyroid Hormone and Calcitonin*
1980; Oxford University Press; Volume: 1; Issue: 4 Linguagem: Inglês
10.1210/edrv-1-4-319
ISSN1945-7189
Autores Tópico(s)Genetic Syndromes and Imprinting
ResumoIonic and nonionic control of parathyroid hormone and calcitonin secretion There is general agreement that the plasma concentration of calcium is the dominant regulator of parathyroid hormone (PTH) secretion (1–4) and probably also of calcitonin (CT) release (5, 6). Calcium stimulates CT secretion but inhibits PTH release; hypocalcemia has the opposite effects. Under certain conditions, other divalent cations, especially magnesium, can influence PTH and CT secretion in a fashion parallel to that of calcium, but there is little evidence that these relationships are of importance within the physiological range (3, 4). Normal secretion of PTH does, however, require the presence of magnesium (8, 9). Absence of the chloride and hydroxyl anions impairs PTH release in vitro (10), but it seems unlikely that levels of those anions have a specific regulatory function in calcium homeostasis. Phosphate infusion stimulates PTH secretion only by lowering plasma ionic calcium levels (2, 11), and an early report (12) that phosphate raised plasma immunoreactive CT (iCT) concentrations has not been verified (13).
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