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An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media

2011; Royal Society of Chemistry; Volume: 13; Issue: 12 Linguagem: Inglês

10.1039/c1gc15868f

1463-9270

Manoj B. Gawande, Paula S. Branco,

Covalent Organic Framework Applications

A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles.