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Haploidentical stem cell transplantation as a salvage therapy for cord blood engraftment failure in a patient with Fanconi anemia

2010; Wiley; Volume: 55; Issue: 3 Linguagem: Inglês

10.1002/pbc.22584

1545-5017

Rawad Rihani, Isam Lataifeh, Hadeel Halalsheh, Ayad Ahmed Hussein, Abdulhadi Al‐Zaben, Fawzi Abdel‐Rahman, Mahmoud Sarhan,

Prenatal Screening and Diagnostics

A 7-year-old male with Fanconi Anemia who developed primary graft failure following one antigen-mismatched unrelated cord blood transplantation and a nonradiation-based conditioning, underwent a second hematopoietic stem cell transplantation (HSCT) from his 2-loci mismatched haploidentical father, using a nonradiation-based regimen, 79 days after the first HSCT. A sustained hematological engraftment was achieved at 9 days post-second HSCT. At 15 months post-second HSCT; the patient demonstrated normal blood counts, sustained donor chimerism, and no evidence of GVHD. Haploidentical HSCTs as primary or secondary sources of stem cells, with appropriate T-cell depletion, may be a readily available option in the absence of HLA-matched related or unrelated donors.