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682 PRESENCE OF URETERAL TUMOR WAS ASSOCIATED WITH POOR PROGNOSIS IN UPPER URINARY TRACT UROTHELIAL CARCINOMA PATIENTS TREATED BY NEPHROURETERECTOMY: A MULTICENTER DATABASE STUDY OF 1063 PATIENTS

2013; Lippincott Williams & Wilkins; Volume: 189; Issue: 4S Linguagem: Inglês

10.1016/j.juro.2013.02.238

1527-3792

Yuma Waseda, Kazutaka Saito, Junichiro Ishioka, Yoh Matsuoka, Noboru Numao, Fumitaka Koga, Hitoshi Masuda, Yasuhisa Fujii, Yasuyuki Sakai, Tetsuo Okuno, Chizuru Arisawa, Shigeyoshi Kamata, K Nagahama, Junji Yonese, Akira Noro, Toshihiko Tsujii, Shinji Morimoto, Yotsuo Higashi, Iwao Fukui, Kazunori Kihara,

Urologic and reproductive health conditions

You have accessJournal of UrologyUrothelial Cancer: upper Tract Tumors (I)1 Apr 2013682 PRESENCE OF URETERAL TUMOR WAS ASSOCIATED WITH POOR PROGNOSIS IN UPPER URINARY TRACT UROTHELIAL CARCINOMA PATIENTS TREATED BY NEPHROURETERECTOMY: A MULTICENTER DATABASE STUDY OF 1063 PATIENTS Yuma Waseda, Kazutaka Saito, Junichiro Ishioka, Yoh Matsuoka, Noboru Numao, Fumitaka Koga, Hitoshi Masuda, Yasuhisa Fujii, Yasuyuki Sakai, Tetsuo Okuno, Chizuru Arisawa, Shigeyoshi Kamata, Katsuji Nagahama, Junji Yonese, Akira Noro, Toshihiko Tsujii, Shinji Morimoto, Yotsuo Higashi, Iwao Fukui, and Kazunori Kihara Yuma WasedaYuma Waseda Tokyo, Japan , Kazutaka SaitoKazutaka Saito Tokyo, Japan , Junichiro IshiokaJunichiro Ishioka Tokyo, Japan , Yoh MatsuokaYoh Matsuoka Tokyo, Japan , Noboru NumaoNoboru Numao Tokyo, Japan , Fumitaka KogaFumitaka Koga Tokyo, Japan , Hitoshi MasudaHitoshi Masuda Tokyo, Japan , Yasuhisa FujiiYasuhisa Fujii Tokyo, Japan , Yasuyuki SakaiYasuyuki Sakai chiba, Japan , Tetsuo OkunoTetsuo Okuno Ibaraki, Japan , Chizuru ArisawaChizuru Arisawa Tokyo, Japan , Shigeyoshi KamataShigeyoshi Kamata Saitama, Japan , Katsuji NagahamaKatsuji Nagahama chiba, Japan , Junji YoneseJunji Yonese Tokyo, Japan , Akira NoroAkira Noro Saitama, Japan , Toshihiko TsujiiToshihiko Tsujii Tokyo, Japan , Shinji MorimotoShinji Morimoto Ibaraki, Japan , Yotsuo HigashiYotsuo Higashi Saitama, Japan , Iwao FukuiIwao Fukui Tokyo, Japan , and Kazunori KiharaKazunori Kihara Tokyo, Japan View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.238AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The prognostic significance of tumor location for patients with upper urinary tract urothelial carcinoma (UUT-UC) has been disputed. Several reports have suggested the tendency of worse prognosis of patients with a ureteral tumor as the dominant lesion. We investigated the prognostic significance of the presence of ureteral tumor regardless of dominancy to evaluate the significance of tumor location in UUT-UC patients using a multicenter database. METHODS Among 1329 UUT-UC patients in Tokyo Metropolitan Database of Urologic disease (TMDU), 1063 patients who underwent radical nephroureterectomy without concurrent radical cystectomy and whose data were complete and available were eligible for the study. Patients who had a ureteral tumor, despite the presence of renal pelvic tumor, were categorized in the ureteral tumor group. Patients with only renal pelvic tumors were categorized in the renal pelvic tumor group. Cox proportional hazards model was used to evaluate prognostic significance of each factor on cancer-specific survival (CSS). RESULTS During the follow-up period (median 38 months, interquartile range 16 to 76 months), 236 (22%) patients died of disease. The 5- and 10-year CSS rates of the total 1063 patients were 73% and 68%, respectively. The renal pelvic and the ureteral tumor groups consisted of 498 (47%) and 565 (53%) patients, respectively. The ureteral tumor group had a higher stage, grade, rate of lymphvascular invasion (LVI) and lymph node metastasis compared to the renal pelvic group. In a multivariate analysis, the presence of a ureteral tumor was a significant prognostic factor for CSS as were age, performance status, pT stage, grade, LVI and pN. The ureteral group 5-year CSS rate (67%) was worse than that of the renal pelvic tumor group (80%; p<0.001). CONCLUSIONS In our current cohort, the presence of a ureteral tumor had a significant impact on the survival of UUT-UC patients treated surgically. The presence of a ureteral tumor was associated with poor prognosis. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e280 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yuma Waseda Tokyo, Japan More articles by this author Kazutaka Saito Tokyo, Japan More articles by this author Junichiro Ishioka Tokyo, Japan More articles by this author Yoh Matsuoka Tokyo, Japan More articles by this author Noboru Numao Tokyo, Japan More articles by this author Fumitaka Koga Tokyo, Japan More articles by this author Hitoshi Masuda Tokyo, Japan More articles by this author Yasuhisa Fujii Tokyo, Japan More articles by this author Yasuyuki Sakai chiba, Japan More articles by this author Tetsuo Okuno Ibaraki, Japan More articles by this author Chizuru Arisawa Tokyo, Japan More articles by this author Shigeyoshi Kamata Saitama, Japan More articles by this author Katsuji Nagahama chiba, Japan More articles by this author Junji Yonese Tokyo, Japan More articles by this author Akira Noro Saitama, Japan More articles by this author Toshihiko Tsujii Tokyo, Japan More articles by this author Shinji Morimoto Ibaraki, Japan More articles by this author Yotsuo Higashi Saitama, Japan More articles by this author Iwao Fukui Tokyo, Japan More articles by this author Kazunori Kihara Tokyo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...