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Chemical composition and in vitro schistosomicidal activity of the essential oil from the flowers of Bidens sulphurea (Asteraceae)

2012; Taylor & Francis; Volume: 27; Issue: 10 Linguagem: Inglês

10.1080/14786419.2012.671314

1478-6427

Graciele Almeida de Aguiar, Nathalya Isabel de Melo, Kamila A. L. Wakabayashi, Machado Lopes, André L. L. Mantovani, Herbert Júnior Dias, Murilo J. Fukui, Larissa Costa Keles, Veridiana de Melo Rodrigues, Milton Groppo, A.A. Silva-Filho, Wilson Roberto Cunha, Lizandra Guidi Magalhães, Antônio Eduardo Miller Crotti,

Global Maternal and Child Health

In this study, the chemical composition and the in vitro schistosomicidal properties of the essential oil obtained from Bidens sulphurea flowers (Bs-EO) were investigated. Its major constituents were identified as being 2,6-di-tert-butyl-4-methylphenol (44.98%), germacrene D (33.70%) and β-caryophyllene (10.23%). Bs-EO at 100 µg mL−1 caused death of all the adult worms and promoted separation of the couple pairs into individual male and female within 48 h, besides leading to a significant decrease in the motility of the parasites. This oil was also responsible for a remarkable reduction in the number of eggs and the percentage of developed eggs produced by adult worms. These results suggest that the Bs-EO can be considered a promising source for the development of new schistosomicidal agents.