Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution
2002; National Academy of Sciences; Volume: 99; Issue: 3 Linguagem: Inglês
10.1073/pnas.251664698
ISSN1091-6490
AutoresDavid Bushnell, Patrick Cramer, Roger D. Kornberg,
Tópico(s)Heat shock proteins research
ResumoThe structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
Referência(s)