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Revisão Revisado por pares
BIBTEX RIS

Regulating the onset of mitosis

1999; Elsevier BV; Volume: 11; Issue: 2 Linguagem: Inglês

10.1016/s0955-0674(99)80036-2

ISSN

1879-0410

Autores

Ryoma Ohi, Kathleen L. Gould,

Tópico(s)

DNA Repair Mechanisms

Resumo

In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition. Altering the spatial organization of G2/M regulators also contributes to prevention of mitosis following DNA damage.

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