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Reduction of Fe(III)ADP complex by liver microsomes

1988; Elsevier BV; Volume: 964; Issue: 2 Linguagem: Inglês

10.1016/0304-4165(88)90160-2

1872-8006

Miklós Végh, Attila Marton, István T. Horváth,

Paraquat toxicity studies and treatments

An NADPH-driven enzymatic reduction of an Fe(III)ADP complex by rat liver microsomes has been demonstrated directly for the first time during the initial phase of lipid peroxidation by using two different analytical methods. The reduction rate increased upon increasing the ratio of ADP to ferric iron. Fe(III)ADP reducing activity of both detergent-solubilized microsomes and purified NADPH:cytochrome-P-450 (cytochrome-c) reductase decreased to about 20% compared to that of the native microsomes. Superoxide dismutase and KCN did not inhibit the reduction.