Portal de Periódicos da CAPES

Small-Cell Cancer of the Breast: What Is the Optimal Treatment? A Report and Review of Outcomes

2012; Elsevier BV; Volume: 12; Issue: 4 Linguagem: Inglês

10.1016/j.clbc.2012.03.007

1938-0666

Roberto Ochoa, Ashkay Sudhindra, Mónica García-Buitrago, A. Pat Romilly, Javier Cortés, Henry Gómez, Caio M. Rocha Lima, Orlando Silva,

Cancer therapeutics and mechanisms

Clinical Practice Points •Small-cell cancer of the breast is a very rare malignancy with fewer than 50 cases reported in the past 30 years. •Different treatments, including surgery, chemotherapy, and radiation alone and in different combinations have been reported with no clear suggestions on what is the optimal treatment. •We report the use of cisplatinum and etoposide in a young patient with metastatic disease with a short-lived initial response. •Review of clinical information in 48 reported cases seems to suggest that patients with early-stage disease can be successfully treated with surgery followed by chemotherapy and radiation. •Cisplatinum and etoposide have been used preoperatively in patients with stage III disease with some achieving pathologic complete response and long-term disease free survival. •As opposed to small-cell cancer of the lung, there seems to be an important role for surgery in patients with localized disease and should be pursued whenever possible. •Small-cell cancer of the breast is a very rare malignancy with fewer than 50 cases reported in the past 30 years. •Different treatments, including surgery, chemotherapy, and radiation alone and in different combinations have been reported with no clear suggestions on what is the optimal treatment. •We report the use of cisplatinum and etoposide in a young patient with metastatic disease with a short-lived initial response. •Review of clinical information in 48 reported cases seems to suggest that patients with early-stage disease can be successfully treated with surgery followed by chemotherapy and radiation. •Cisplatinum and etoposide have been used preoperatively in patients with stage III disease with some achieving pathologic complete response and long-term disease free survival. •As opposed to small-cell cancer of the lung, there seems to be an important role for surgery in patients with localized disease and should be pursued whenever possible.