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Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases

2005; Elsevier BV; Volume: 5; Issue: 3 Linguagem: Inglês

10.1016/j.coph.2005.01.011

1471-4973

James F. Tobin, Anthony Celeste,

Muscle metabolism and nutrition

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy.