Portal de Periódicos da CAPES

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

2010; American Medical Association; Volume: 68; Issue: 1 Linguagem: Inglês

10.1001/archneurol.2010.225

1538-3687

Laura D. Baker, Donna J. Cross, Satoshi Minoshima, Dana Belongia, G. Stennis Watson, Suzanne Craft,

Alzheimer's disease research and treatments

Background: Insulin resistance is a causal factor in prediabetes (PD) and type 2 diabetes (T2D) and increases the risk of developing Alzheimer disease (AD).Reductions in cerebral glucose metabolic rate (CMRglu) as measured by fludeoxyglucose F 18-positron emission tomography (FDG-PET) in parietotemporal, frontal, and cingulate cortices are associated with increased AD risk and can be observed years before dementia onset.Objectives: To examine whether greater homeostasis model assessment insulin resistance (HOMA-IR) is associated with reduced resting CMRglu in areas vulnerable in AD in cogni-tivelynormaladultswithnewlydiagnosedPDorT2D(PD/T2D), and to determine whether adults with PD/T2D have abnormal patterns of CMRglu during a memory encoding task.Design: Randomized crossover design of resting and activation FDG-PET.