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High throughput paper spray mass spectrometry analysis

2012; Elsevier BV; Volume: 420; Linguagem: Inglês

10.1016/j.cca.2012.10.025

1873-3492

Luhou Shen, Johnny Zhang, Qian Yang, Nicholas E. Manicke, Zheng Ouyang,

Pharmacological Effects and Assays

Fast analysis of chemicals in samples of complex mixtures is important for many analytical applications including therapeutic drug monitoring and food safety screening.Based on the paper spray technology developed recently, a high throughput device was developed in this work and used for evaluation of the fast quantitative analysis using paper spray mass spectrometry.The performance of the method was characterized with bovine blood samples spiked with sunitinib and nicotine. At optimized condition, relatively fast analysis speed of 7s/sample was achieved with relatively good LOQs (1 ng/ml) and quantitation.In an application of the method for food screening, LODs better than 1 ng/g were achieved for clenbuterol in beef.