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Animal models of inflammatory bowel disease

2004; Elsevier BV; Volume: 50; Issue: 2 Linguagem: Inglês

10.1016/j.vascn.2003.12.002

1873-488X

Abdo Jurjus, Naïm Khoury, Jean‐Marie Reimund,

Helicobacter pylori-related gastroenterology studies

In inflammatory bowel disease (IBD), experimental models have proven to be important tools for detecting potential therapeutic agents and for investigating the mechanisms of pathogenesis. This review is intended to cover recent advances in basic IBD model applications. The use of more than 20 animal models has allowed the detection of numerous protective pharmacological agents, including a number of immunomodulatory agents that have entered the therapeutic armamentarium. The models have been classified into five main categories based on the methods of induction: gene knockout (KO), transgenic, chemical, adoptive transfer, and spontaneous (each with subcategories).