Fast, efficient and selective deprotection of the tert ‐butoxycarbonyl (Boc) group using HCl/dioxane (4 m )
2001; Wiley; Volume: 58; Issue: 4 Linguagem: Inglês
10.1034/j.1399-3011.2001.00935.x
ISSN1399-3011
AutoresG. Han, Makoto Tamaki, Victor J. Hruby,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoAbstract: Fast, efficient and selective deprotection of the tert ‐butoxycarbonyl (Boc) group of various amino acids and peptides was achieved by using hydrogen chloride (4 m ) in anhydrous dioxane solution for 30 min at room temperature. In the cases studied in our laboratory, this protocol provided superior selectivity to deprotect N α ‐Boc groups in the presence of tert ‐butyl esters and tert ‐butyl ethers, including thio‐ tert ‐butyl ethers, but not phenolic tert ‐butyl ethers.
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