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Acetaminophen and Liver Disease

1978; American College of Physicians; Volume: 88; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-88-1-129_1

1539-3704

David M. Rosenberg,

Liver Disease and Transplantation

Letters and Corrections1 January 1978Acetaminophen and Liver DiseaseDAVID M. ROSENBERG, M.D., FRANCIS A. NEELON, M.D.DAVID M. ROSENBERG, M.D.Search for more papers by this author, FRANCIS A. NEELON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-1-129_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent reports in your journal (1, 2) that modest dosages of acetaminophen can cause liver damage in individuals are interesting. Both Barker, de Carle, and Anuras (1) and Johnson and Tolman (2) speculate that patients with underlying liver disease may be unusually susceptible to the toxic manifestations of acetaminophen.We recently observed (3) severe liver dysfunction in two family members who took acetaminophen (3.6 g/day) for symptoms of infectious mononucleosis. Both of our patients had severe disturbance of hepatic function (husband: bilirubin 14.0 mg/dl (76% direct), serum glutamic oxalacetic transaminase (SGOT) 188 IU, lactic dehydrogenase (LDH)...References1. BARKERDE CARLEANURAS JDS: Chronic excessive acetaminophen use and liver damage. Ann Intern Med 87:299-301, 1977 LinkGoogle Scholar2. JOHNSONTOLMAN GK: Chronic liver disease and acetaminophen. Ann Intern Med 87:302-304, 1977 LinkGoogle Scholar3. ROSENBERGMEYERMANNINGNEELON DAIF: Acetaminophen and hepatic dysfunction in infectious mononucleosis. South Med J 70:660-661, 1977 CrossrefMedlineGoogle Scholar4. GELBWESTZIMMERMAN DMH: Serum enzymes in disease. Am J Med 33:249-261, 1962 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID M. ROSENBERG, M.D.; FRANCIS A. NEELON, M.D.Affiliations: Duke University Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byACETAMINOPHEN HEPATOTOXICITYPrediction of organ system toxicity with antirheumatic drug therapyAcetaminophen Chronic ToxicitySevere hepatic damage after acetaminophen use in psittacosisHepatic reactions to drugs.Antipyretic analgesics 1 January 1978Volume 88, Issue 1Page: 129-129KeywordsAminotransferasesBilirubinDehydrogenasesLactate dehydrogenaseLiverLiver diseasesSerum glutamic oxaloacetic transaminase ePublished: 1 December 2008 Issue Published: 1 January 1978 PDF downloadLoading ...