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SCOPAFUNGIN, A CRYSTALLINE ENDOMYCIN COMPONENT

1972; Springer Nature; Volume: 25; Issue: 1 Linguagem: Inglês

10.7164/antibiotics.25.39

1881-1469

M. E. BERGY, Herman Hoeksema,

Plant Pathogens and Fungal Diseases

Scopafungin is the major component of the non-polyenic endomycin complex which was extracted from Streptomyces hygroscopicus var. enhygrus var. nova and purified by partition column chromatography or silica gel column chromatography followed by crystallization. It is a white crystalline compound which contains carbon (60.95%), hydrogen (9.00%), nitrogen (4.01%) and oxygen (26.46%) and melts at 119.3°C. In methanol, 0.1N HCl in methanol, and 0.1N KOH in methanol, it exhibits maximum UV absorption at 231nm and is dextrorotatory in dimethylformamide, [α]25D+20. Titration in glacial acetic acid indicates an equivalent weight of 1268. Scopafungin is soluble in lower alcohols, glacial acetic acid, acetone - water (3:2) and water-saturated 1-butanol, but is insoluble in water, acetone, ethyl acetate, methyl ethyl ketone, methylene chloride, chloroform, butanol or ether.