Chitin Synthase II Inhibitory Activity of Ursolic Acid, Isolated from Crataegus pinnatifida
1999; Thieme Medical Publishers (Germany); Volume: 65; Issue: 03 Linguagem: Inglês
10.1055/s-2006-960474
ISSN1439-0221
AutoresTae‐Sook Jeong, Eui-Il Hwang, Hyang‐Bok Lee, Eun Sook Lee, Young‐Kook Kim, Byung Sun Min, KiHwan Bae, Song‐Hae Bok, Sung-Uk Kim,
Tópico(s)Natural product bioactivities and synthesis
ResumoTwo triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 microgram/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 micrograms/ml. Oleanolic acid, alpha-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 micrograms/ml, respectively.
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