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Pyridine as a Borane Scavenger to Avoid Overreduction During the Conversion of Acid Chlorides to the Corresponding Aldehydes Using Sodium Borohydride

1982; Taylor & Francis; Volume: 12; Issue: 11 Linguagem: Inglês

10.1080/00397918208065961

1532-2432

James H. Babler,

Chemical Synthesis and Characterization

Abstract By use of sodium borohydride in N, N-dimethylformamide solution containing a molar excess of pyridine as a borane scavenger, direct conversion of both aliphatic and aromatic acid chlorides to the corresponding aldehydes can be achieved in >70% yield with minimal (5–10%) alcohol formation.