Genetic variation of Omi/HtrA2 and Parkinson's disease
2008; Elsevier BV; Volume: 14; Issue: 7 Linguagem: Inglês
10.1016/j.parkreldis.2008.08.003
ISSN1873-5126
AutoresOwen A. Ross, Alexandra I. Soto, Carles Vilariño‐Güell, Michael G. Heckman, Nancy N. Diehl, Mary Hulihan, Jan Aasly, Sigrid Botne Sando, J. Mark Gibson, Timothy Lynch, Anna Krygowska‐Wajs, Grzegorz Opala, Maria Barcikowska, K Czyźewski, Ryan J. Uitti, Zbigniew K. Wszołek, Matthew J. Farrer,
Tópico(s)Genetics and Neurodevelopmental Disorders
ResumoVariants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.
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