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Thyroid dysfunction and neoplasia in children receiving neck irradiation for cancer

1985; Wiley; Volume: 55; Issue: 6 Linguagem: Inglês

10.1002/1097-0142(19850315)55

1097-0142

Irvin D. Fleming, Timothy L. Black, Elizabeth I. Thompson, Charles B. Pratt, Bhaskar Rao, Omar Hustu,

Salivary Gland Disorders and Functions

CancerVolume 55, Issue 6 p. 1190-1194 ArticleFree Access Thyroid dysfunction and neoplasia in children receiving neck irradiation for cancer Irvin D. Fleming MD, Corresponding Author Irvin D. Fleming MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, Tennessee Department of Surgery, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSt. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38101===Search for more papers by this authorTimothy L. Black MD, Timothy L. Black MD Department of Surgery, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorElizabeth I. Thompson MD, Elizabeth I. Thompson MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorCharles Pratt MD, Charles Pratt MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorBhaskar Rao MD, Bhaskar Rao MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorOmar Hustu MD, Omar Hustu MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this author Irvin D. Fleming MD, Corresponding Author Irvin D. Fleming MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, Tennessee Department of Surgery, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSt. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38101===Search for more papers by this authorTimothy L. Black MD, Timothy L. Black MD Department of Surgery, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorElizabeth I. Thompson MD, Elizabeth I. Thompson MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorCharles Pratt MD, Charles Pratt MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorBhaskar Rao MD, Bhaskar Rao MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this authorOmar Hustu MD, Omar Hustu MD St. Jude Children's Research Hospital, University of Tennessee Center for the Health Sciences, Memphis, TennesseeSearch for more papers by this author First published: 15 March 1985 https://doi.org/10.1002/1097-0142(19850315)55:6 3.0.CO;2-6Citations: 52AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The reported relationship of radiation exposure and thyroid carcinoma stimulated this retrospective study of 298 patients treated at St. Jude Children's Hospital with radiation therapy to the neck for childhood cancer to identify patients who developed subsequent thyroid abnormalities. This series includes 153 patients with Hodgkin's disease, 95 with acute lymphocytic leukemia, 28 with lymphoepi-thelioma, and 22 with miscellaneous tumors. Inclusion in the study required 5 years of disease-free survival following therapy for their original tumor, which included thyroid irradiation. Follow-up has been 100%. Most patients also received chemotherapy. Seventeen patients were found to have decreased thyroid reserve with normal levels of free triiodothyroxine (T3) or free thyroxin, (T4) and an elevated level of thyroid-stimulating hormone (TSH). In nine patients hypothyroidism developed, with decreased T3 or T4 levels and an elevated level of TSH. One hyperthyroid patient was identified. Two patients had thyroiditis, and seven had thyroid neoplasms: (carcinoma in two, adenoma in two, colloid nodule in one, and undiagnosed nodules in two). This survey has demonstrated an increased incidence of thyroid dysfunction and thyroid neoplasia when compared to the general population. The importance of long-term follow-up for thyroid disease is emphasized in patients who have received thyroid irradiation. The possible role of subclinical hypothyroidism with TSH elevation coupled with radiation darnage to the thyroid gland as a model for the development of neoplastic disease is discussed. Cancer 55:1190-1194, 1985. Reference 1 Prentice RL, Kato H, Yashimoto K, Mason M. Radiation exposure and thyroid cancer incidence among Hiroshima and Nagasaki residents. 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Multiple primary cancer risk after therapy for Hodgkin's disease. Cancer 1977; 40: 1917–1926. Citing Literature Volume55, Issue615 March 1985Pages 1190-1194 ReferencesRelatedInformation