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Artigo Revisado por pares
BIBTEX RIS

Metabolites of Orally Active NO-Independent Pyrazolopyridine Stimulators of Soluble Guanylate Cyclase

2002; Elsevier BV; Volume: 10; Issue: 6 Linguagem: Inglês

10.1016/s0968-0896(02)00034-2

ISSN

1464-3391

Autores

Andreas Straub,

Tópico(s)

Adenosine and Purinergic Signaling

Resumo

The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543.

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