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Human resistin in cardiovascular disease

2012; Japan Society of Smooth Muscle Research; Volume: 48; Issue: 1 Linguagem: Inglês

10.1540/jsmr.48.27

1884-8796

Sang Eun Lee, Hyo-Soo Kim,

Regulation of Appetite and Obesity

An adipokine, resistin, was first discovered as a potential mediator of obesity related insulin resistance in rodents.However, the relevance of resistin in human obesity and insulin resistance has been challenged by the difference between human and rodent resistin and the controversies in human epidemiologic studies.Instead, recent human clinical studies and experiments support the idea that human resistin is an inflammatory mediator and a biomarker of cardiovascular diseases, especially in atherosclerosis and heart failure.Thus, we focused on the recent evidence of the role of human resistin in cardiovascular disease.