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BIBTEX RIS

An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera

2011; Taylor & Francis; Volume: 26; Issue: 21 Linguagem: Inglês

10.1080/14786419.2011.639070

1478-6427

Héctor H. F. Koolen, Elzalina Ribeiro Soares, Felipe M. A. da Silva, Antônia Queiroz Lima de Souza, Afonso Duarte Leão de Souza, Edson Rodrigues‐Filho, Richardson Alves de Almeida, Ismael Alexandre Ribeiro, Cláudia Pessoa, Manoel Odorico de Morais, Patrícia Marçal da Costa, Afonso Duarte Leão de Souza,

Marine Sponges and Natural Products

From an endophytic strain of Gliocladium sp. isolated from the Amazonian plant Strychnos cf. toxifera, we obtained the diketopiperazine alkaloid cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether (1), the steroids ergosterol (2), ergosterol peroxide (3), cerevisterol (4) and the citric acid (5). The AcOEt extract of the fermented broth by Gliocladium sp. showed potent activity against the cancer cell lines MDA-MB435 (human breast cancer cells), HCT-8 (human colorectal cancer cells) and SF-295 (human glioblastoma cancer cells). Compound 1 exhibited a strong antimicrobial activity against Micrococcus luteus at a concentration of 43.4 µM.