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Neutrophil granules and secretory vesicles in inflammation

2003; Elsevier BV; Volume: 5; Issue: 14 Linguagem: Inglês

10.1016/j.micinf.2003.09.008

1769-714X

Mikkel Faurschou, Niels Borregaard,

S100 Proteins and Annexins

The neutrophil is a major effector cell of innate immunity. Exocytosis of granules and secretory vesicles plays a pivotal role in most neutrophil functions from early activation to the destruction of phagocytosed microorganisms. Neutrophil granules contain a multitude of antimicrobial and potentially cytotoxic substances that are delivered to the phagosome or to the exterior of the cell following degranulation. This review summarises current knowledge of granule biology and highlights the effects of neutrophil degranulation in the acute inflammatory response.