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Determinação de metil-etil-cetona em amostras de urina com amostragem por micro extração em fase sólida (MEFS) em headspace associada à cromatografia gasosa com detector de ionização de chama (CG-DIC)

2008; Brazilian Chemical Society; Volume: 31; Issue: 8 Linguagem: Inglês

10.1590/s0100-40422008000800043

ISSN

1678-7064

Autores

Marina Venzon Antunes, Rafael Linden,

Tópico(s)

Effects and risks of endocrine disrupting chemicals

Resumo

FLAME-IONIZATION DETECTOR (GC-FID).Methyl ethyl ketone (MEK) is a solvent commonly used in chemical, paint and shoe industry.The aim of this study was to develop and validate a method for urinary quantification of MEK, employing headspace solid phase micro extraction sampling (SPME) coupled to gas chromatography with flame ionization detection (GC-FID).The calibration curve (y=4.6851x-0.0011)presented good linearity with r 2 =0.9993.Accuracy (94-109%), intra-assay precision (4.07-5.91%)and inter-assay precision (3.03-5.62%)were acceptable.The quantification limit was 0.19 mg/L.This low cost method can be used routinely in the biological monitoring of occupational exposure to MEK, according to the requirements of the Brazilian legislation.

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