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Artigo Revisado por pares
BIBTEX RIS

The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis

2012; Elsevier BV; Volume: 243; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2011.11.008

ISSN

1872-8421

Autores

María Jesús Pinto-Medel, Juan Antonio García‐León, Begoña Oliver‐Martos, Carlos Lopez‐Gómez, Gloria Luque Agulló, Carlos Arnáiz-Urrutia, Teresa Órpez, Carmen Marín-Bañasco, Óscar Fernández, Laura Leyva,

Tópico(s)

Immune Cell Function and Interaction

Resumo

Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, leading to the generation of CD28(-) T-cells. Our aim was to examine whether CD4(+)CD28(-) T-cells were enriched in MS patients, and characterize the phenotype of this subset in MS patients and healthy controls (HC). All these changes could provide these CD4(+)CD28(-) T-cell characteristics that might be involved in the pathogenesis of MS, turning this T-cell subset into a potential target for future therapeutic strategies.

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