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Activity against Plasmodium falciparum of Lactones Isolated from the Endophytic Fungus Xylaria sp.

2008; Taylor & Francis; Volume: 46; Issue: 10-11 Linguagem: Inglês

10.1080/13880200802215859

1744-5116

Carlos Jiménez‐Romero, Eduardo Ortega-Barrı́a, A. Elizabeth Arnold, Luis Cubilla‐Rios,

Plant and fungal interactions

Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μ g/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1–3 against a chloroquine-resistant Plasmodium falciparum strain.