Portal de Periódicos da CAPES

Transition of mechanical property of porous alginate scaffold with cells during culture period

2005; Elsevier BV; Volume: 100; Issue: 1 Linguagem: Inglês

10.1263/jbb.100.127

1389-1723

Shinji Sakai, Hiroki Masuhara, Yusuke Yamada, Tsutomu Ono, Hiroyuki Ijima, Koei Kawakami,

Bone Tissue Engineering Materials

The rupture forces of porous alginate scaffolds seeded with hepatocytes or fibroblast-like cells increased during 3 d of culture and then decreased. The phenomenon was independent of the number of viable cells within the scaffolds, but dependent on protein adsorption to the alginate as well as a reduction in the degree of crosslinks of the calcium-alginate gel.