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Search for compounds which have an inhibitory effect on rhabdovirus multiplication In Vitro

1983; Elsevier BV; Volume: 134; Issue: 1 Linguagem: Inglês

10.1016/s0769-2617(83)80048-3

1879-2820

F. Bussereau, Jean‐Claude Chermann, D. De Clercq, C Hannoun,

Plant Virus Research Studies

Summary Twenty-one substances were investigated in vitro against rhabdovirus infections. The inhibitory effect was evaluated under single-growth cycle conditions. The substance was present in the culture medium during the entire growth cycle at doses varying from 5 to 500 μg/ml. At non-cytotoxic doses, inhibition of rabies virus production was achieved by thirteen substances. Eight of them—7 heteropolyanions and virazole—showed a dose-dependent inhibition, while the others—four acyclic derivatives of adenosine and carbocyclic 3-deazaadenosine—showed a 90 % inhibition whatever the dose. Under the same conditions, none of these thirteen substances inhibited the production of vesicular stomatitis virus. Only one compound, amantadine, inhibited the production of both viruses.