The Regulation of the Drosophila Gene Reveals a Function for in Translational Control
1997; Cell Press; Volume: 89; Issue: 5 Linguagem: Inglês
10.1016/s0092-8674(00)80262-7
ISSN1097-4172
AutoresGreg J. Bashaw, Bruce S. Baker,
Tópico(s)Neurobiology and Insect Physiology Research
ResumoIn Drosophila, dosage compensation occurs by increasing the transcription of the single male X chromosome. Four trans-acting factors encoded by the male-specific lethal genes are required for this process. Dosage compensation is restricted to males by the splicing regulator Sex-lethal, which functions to prevent the production of the MSL-2 protein in females by an unknown mechanism. In this report, we provide evidence that Sex-lethal acts synergistically through sequences in both the 5′ and 3′ untranslated regions of MSL-2 to mediate repression. We also provide evidence that the repression of MSL-2 is directly regulated by Sex-lethal at the level of translation.
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