Produção Nacional
Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions
2012; Hindawi Publishing Corporation; Volume: 2012; Linguagem: Inglês
10.1155/2012/379024
ISSN1110-7251
AutoresSandro Massao Hirabara, Renata Gorjão, Marco Aurélio Ramirez Vinolo, Alice Cristina Rodrigues, Renato Tadeu Nachbar, Rui Curi,
Tópico(s)Apelin-related biomedical research
ResumoInflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2 diabetes mellitus , metabolic syndrome, cancer, and cardiovascular diseases. Various studies show a relationship between these two factors, although the mechanisms involved are not completely understood yet. Here, we discuss the molecular basis of insulin resistance and inflammation and the molecular aspects on inflammatory pathways interfering in insulin action. Moreover, we explore interventions based on molecular targets for preventing or treating correlated disorders, advances for a better characterization, and understanding of the mechanisms and mediators involved in the different inflammatory and insulin resistance conditions. Finally, we address biotechnological studies for the development of new potential therapies and interventions.
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