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Are stress proteins part of a cell's solution to toxicity or are they part of the problem?

1997; Lippincott Williams & Wilkins; Volume: 25; Issue: 5 Linguagem: Inglês

10.1002/hep.510250539

1527-3350

Lawrence E. Hightower, J. A. Ryan,

Enzyme Structure and Function

HepatologyVolume 25, Issue 5 p. 1279-1281 EditorialFree Access Are stress proteins part of a cell's solution to toxicity or are they part of the problem? L E Hightower, L E HightowerSearch for more papers by this authorJ A Ryan, J A RyanSearch for more papers by this author L E Hightower, L E HightowerSearch for more papers by this authorJ A Ryan, J A RyanSearch for more papers by this author First published: 30 December 2003 https://doi.org/10.1002/hep.510250539Citations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Feige U, Morimoto RI, Yahara I, Polla BS. Stress–inducible cellular responses. Basel: Birkhäuser Verlag, 1996. 2 Morimoto RI, Tissières A, Georgopoulos C. The Biology of Heat Shock Proteins and Molecular Chaperones. Plainview: Cold Spring Harbor Laboratory Press, 1994. 3 van Eden W, Young DB. Stress Proteins in Medicine. New York: Marcel Dekker, 1996. 4 Renfro JL, Brown MA, Parker SL, Hightower LE. Relationship of thermal and chemical tolerance to trans epithelial transport by cultured flounder renal epithelium. J Pharm Exper Therap 1993; 265: 992– 1000. 5 Liu H, Lightfoot R, Stevens JL. Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols. J Biol Chem 1996; 271: 4805– 4812. 6 Hightower LE. Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 1991; 66: 191– 197. 7 Ryan JA, Hightower LE. 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Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells. Cell Stress Chap 1996; 1: 33– 39. 22 Morimoto RI, Kroeger PE, Cotto JJ. The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions. In: U Feige, RI Morimoto, I Yahara, BS Polla, eds. Stress – Inducible Cellular Responses. Basel: Birkhauser Verlag, 1996: 139– 163. 23 DiDomenico BJ, Bugaisky GE, Lindquist S. The heat shock response is self-regulated at both the transcriptional and posttranslational levels. Cell 1982; 31: 593– 603. 24 Beckmann RP, Lovett M, Welch WJ. Examining the function and regulation of hsp-70 in cells subjected to metabolic stress. J Cell Biol 1992; 117: 1137– 1150. 25 Salminen WF, Voellmy R, Roberts SM. Induction of hsp 70 in HepG2 cells in response to hepatotoxicants. Toxicol Appl Pharmacol 1996; 141: 117– 123. 26 Weber L. Relationship of heat shock proteins and induced thermal resistence. Cell Prolif 1992; 25: 101– 113. 27 Welch WJ, Brown CR. Influence of molecular and chemical chaperones on protein folding. Cell Stress Chap 1996; 1: 109– 115. Citing Literature Volume25, Issue5May 1997Pages 1279-1281 ReferencesRelatedInformation