High-resolution scanning tunneling microscopy imaging of DNA molecules on Cu(111) surfaces
1999; Elsevier BV; Volume: 432; Issue: 3 Linguagem: Inglês
10.1016/s0039-6028(99)00623-8
ISSN1879-2758
AutoresHiroyuki Tanaka, Chiho Kataoka-Hamai, Takashi Kanno, Tomoji Kawai,
Tópico(s)Surface and Thin Film Phenomena
ResumoUsing the pulse injection method, single-stranded DNA and double-stranded plasmid DNA have been deposited on well-defined Cu(111) surfaces under ultrahigh vacuum (UHV) conditions to obtain high-resolution scanning tunneling microscope (STM) images. These particular UHV-STM images have revealed that DNA molecules are adsorbed directly onto a clean Cu(111) surface and exhibited the detailed structures of DNA, which has not been resolved previously. The single-stranded DNA oligomers have exhibited the images of individual internal base molecules and the helix structures made of complementary base sequences. For the double-stranded plasmid DNA, the images have shown the Watson–Crick double-helix structure.
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