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Gender Differences in Seasonal Variation of Urine Stone Risk Factors

2003; Lippincott Williams & Wilkins; Volume: 170; Issue: 2 Linguagem: Inglês

10.1097/01.ju.0000071721.91229.27

1527-3792

Joan H. Parks, Robert F. Barsky, Fredric L. Coe,

Urinary Tract Infections Management

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Aug 2003Gender Differences in Seasonal Variation of Urine Stone Risk Factors JOAN H. PARKS, ROBERT BARSKY, and FREDRIC L. COE JOAN H. PARKSJOAN H. PARKS , ROBERT BARSKYROBERT BARSKY , and FREDRIC L. COEFREDRIC L. COE View All Author Informationhttps://doi.org/10.1097/01.ju.0000071721.91229.27AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether men and women differ in urine stone risk factors during the 4 seasons of the year. Materials and Methods: Measurements from 28,498, 24-hour urines from stone forming patients prior to treatment were analyzed to determine whether monthly variation was significant and whether the sexes differed using ANOVA. Locations of supersaturation maxima were determined. Results: The 2 sexes showed modest sodium depletion in summer with a corresponding decrease in urine calcium but men showed a remarkable decrease in urine volume, causing high calcium oxalate supersaturation. Women had maximum calcium oxalate supersaturation in early winter because of decreasing urine volume and increasing urine calcium excretion. Urine pH was reduced in the 2 sexes during summer but the decrease was far more marked in men, who had a uric acid supersaturation spike. Purpose: Overall the sexes differ markedly in the timing of stone risk. Men show a dual summer calcium oxalate and uric acid high risk, while women show a high early winter calcium oxalate high risk. References 1 : Seasonal variations in urinary risk factors among patients with nephrolithiasis. J Lithotr Stone Dis1991; 3: 18. Google Scholar 2 : Seasonal variations in the composition of urine in relation to calcium stone-formation. Clin Sci Mol Med1975; 49: 597. Google Scholar 3 : Seasonal variations in urinary excretion of calcium and oxalate in normal subjects in patients with idiopathic hypercalciuria. Br J Urol1977; 49: 1. Google Scholar 4 : Seasonal variation in urinary excretion of calcium, oxalate, magnesium and phosphate on free and standard mineral diet in men with urolithiasis. Scand J Urol Nephrol1981; 15: 137. Google Scholar 5 : Equil2: a basic computer program for the calculation of urinary saturation. J Urol1985; 134: 1242. Link, Google Scholar 6 : Differences in urine volume and supersaturation in 2 physician networks. J Urol2001; 166: 423. Link, Google Scholar 7 : Supersaturation and stone composition in a network of dispersed treatment sites. J Urol1998; 159: 1821. Link, Google Scholar 8 : Correspondence between stone composition and urine supersaturation in nephrolithiasis. Kidney Int1997; 51: 894. Google Scholar 9 : A urinary calcium-citrate index for the evaluation of nephrolithiasis. Kidney Int1986; 30: 85. Google Scholar 10 : Stones due to bowel disease. In: Kidney Stones: Medical and Surgical Management. Edited by . Philadelphia: Lippincott-Raven, chapt. 391996: 883. Google Scholar 11 : The importance of renal net acid excretion as a determinant of fasting urinary calcium excretion. Kidney Int1986; 29: 743. Google Scholar 12 : New insights into the pathophysiology and treatment of nephrolithiasis: new research venues. J Bone Miner Res1997; 12: 522. Google Scholar 13 : The contribution of dietary purine over-consumption to hyperpuricosuria in calcium oxalate stone formers. J Chronic Dis1976; 29: 793. Google Scholar 14 : Solution chemistry of supersaturation. In: Kidney Stones: Medical and Surgical Management. Edited by . Philadelphia: Lippincott-Raven, chapt. 21996: 33. Google Scholar From the Nephrology Section, University of Chicago (JHP, FLC), Chicago, Illinois, and Mid-Atlantic Stone Center (RB), Cherry Hill, New Jersey© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 170Issue 2August 2003Page: 384-388 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordskidneysexrisk factorscalculiseasonsMetricsAuthor Information JOAN H. PARKS Financial interest in and/or other relationship with LithoLink Corp. More articles by this author ROBERT BARSKY Financial interest in and/or other relationship with Mid Atlantic Stone Center and Urology Associates. More articles by this author FREDRIC L. COE Financial interest in and/or other relationship with LithoLink Corp. More articles by this author Expand All Advertisement PDF DownloadLoading ...