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New molecular pathways in angiogenesis

2003; Springer Nature; Volume: 89; Issue: 2 Linguagem: Inglês

10.1038/sj.bjc.6601107

1532-1827

D C Sullivan, Roy Bicknell,

Angiogenesis and VEGF in Cancer

Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.