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BIBTEX RIS

Evaluation of the association between polymorphisms at the DRD2 locus and stuttering

2011; Springer Nature; Volume: 56; Issue: 6 Linguagem: Inglês

10.1038/jhg.2011.29

ISSN

1435-232X

Autores

Changsoo Kang, Bianca Santos Domingues, Eduardo Sainz, Carlos Eduardo Frigério Domingues, Dennis Drayna, Danilo Moretti‐Ferreira,

Tópico(s)

Phonetics and Phonology Research

Resumo

Based on the report of Lan et al.,1 we sought to replicate the association between stuttering and single-nucleotide polymorphisms (SNPs) that reside in the dopamine D2 receptor (DRD2) gene in additional populations. The only individual significant association observed by Lan et al. was with the C allele of rs6277, a synonymous SNP (Pro319Pro) within the coding sequence of this gene. In their Han Chinese sample of 112 cases and 112 controls, this allele occurred at a frequency of 0.96 in cases and 0.88 in controls, with a reported P-value of 0.001.

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